primed respiratory burst of human but not murine neutrophils Sequential activation of Class IB and Class IA PI 3 Ks is important for
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چکیده
Prepublished online May 5, 2005; Stephens and Phillip T Hawkins Thomas Ruckle, Montserrat Camps, Christian Rommel, Shaun P Jackson, Edwin R Chilvers, Len R Okkenhaug, Bart Vanhaesebroeck, Martin Turner, Louise Webb, Matthias P Wymann, Emilio Hirsch, Alison M Condliffe, Keith Davidson, Karen E Anderson, Chris D Ellson, Tom Crabbe, Klaus primed respiratory burst of human but not murine neutrophils Sequential activation of Class IB and Class IA PI3Ks is important for the
منابع مشابه
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils.
It is well established that preexposure of human neutrophils to proinflammatory cytokines markedly augments the production of reactive oxygen species (ROS) to subsequent stimuli. This priming event is thought to be critical for localizing ROS to the vicinity of the inflammation, maximizing their role in the resolution of the inflammation, and minimizing the damage to surrounding tissue. We have...
متن کاملSequential activation of Class IB and Class IA PI3Ks is important for the primed respiratory burst of human but not murine neutrophils
The Inositide Laboratory and Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, UK 3 Celltech R&D Ltd, 208 Bath Road, Slough, Berkshire SL1 3WE, UK 4 Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK and Dept. Biochemistry and Molecular Biology, Gower Street, London WC1E 6BT, UK 5 Centre of Biomedi...
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